Nanotherapeutics for Flow-Obstructed Blood Vessels

Blood vessel shear stress increase in blood vessel diseases such as atherosclerosis leads to platelet activation and pathological thrombosis

This ability of platelets to target areas of vascular stenosis, such as in regions of atherosclerotic plaque formation, by responding to changes in their physical microenvironment can be the cause of life-threatening stroke. However, this same physical mechanism of platelet activation served as the inspiration for the development of mechanically activated nanotherapeutics that can specifically target drugs to flow-obstructed blood vessels and concentrate thrombolytic agents at these sites 

It has been demonstrated that only 1/100 of the regular treatment dose is needed with the use of nanotherapeutics